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PubMed · 10655030

FGFs, heparan sulfate and FGFRs: complex interactions essential for development.

D M Ornitz
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Abstract

Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for cell surface heparan sulfate proteoglycans. A large body of biochemical and cellular evidence points to a direct role for heparin/heparan sulfate in the formation of an active FGF/FGF receptor signaling complex. However, until recently there has been no direct demonstration that heparan is required for the biological activity of FGF in a developmental system in vivo. A recent paper by Lin et al.(1) has broken through this barrier to demonstrate that heparan sulfate is essential for FGF function during Drosophila development. The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF. BioEssays 22:108-112, 2000.

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AnimalsDrosophilaFibroblast Growth FactorsHeparinHeparan SulfateModels, BiologicalReceptors, Fibroblast Growth FactorSignal TransductionTissue DistributionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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D M Ornitz. 2000. FGFs, heparan sulfate and FGFRs: complex interactions essential for development.. https://doi.org/10.1002/(sici)1521-1878(200002)22%3A2%3C108%3A%3Aaid-bies2%3E3.0.co%3B2-m

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