PubMed Health⌕ Search

PubMed · 10656599

Speech pattern audiometry in hearing impaired children.

Abstract

The aim of this study was to investigate the use of speech pattern audiometry (SPA) in assessing speech perception abilities of a group of 25 children with sensorineural hearing loss, and to compare their aided performance on SPA tests of four different phoneme contrasts with scores achieved on recorded Manchester Junior Word Lists (MJWL) at their most comfortable listening level (MCLL). The listeners were 25 children, 19 with congenital and six with acquired hearing loss aged between eight and 14 years. They were classified into three groups according to the severity of the hearing loss in the better hearing ear (20-60 dB HL, 61-80 dB HL and >81 dB HL). The SPA tests evaluated listeners' ability to identify word-initial plosives differing in the phonetic features of voicing and place of articulation. The main outcome measures were the SPA gradient measures, the SPA labelling function configuration and MJWL scores. The group with the most severe hearing loss (>81 dB HL) showed significantly poorer performance on the SPA tests and MJWL tests than the groups with mild (20-60 dB HL) to moderate (61-80 dB HL) hearing losses. There was significantly better performance on the two plosive voicing contrast tests than the two plosive place contrasts. For the MJWL, the performance of the group with the more severe hearing loss was also significantly different from the mild and moderate hearing loss groups. A MJWL score of up to 75% was associated with the random labelling configuration on all four SPA tests, emphasizing the different aspects of speech perception that were being examined with each type of test. This study suggests that there is a place for SPA as part of the test battery for speech perception testing in hearing-impaired children.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

B Mac Ardle, V Hazan, D Prasher. 1999. Speech pattern audiometry in hearing impaired children.. https://doi.org/10.3109/03005364000000106

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Prevalence and risk factors for persistent faecal carriage of extended spectrum beta-lactamase producing Escherichia coli in a paediatric community population.

OBJECTIVE: To investigate clinical and microbiological factors associated with persistent faecal carriage of extended spectrum beta-lactamase (ESBL) producing Escherichia coli in infants. METHODS: Between 2010 and 2022, children aged 3 months to 2 years old were sampled in a community setting in France, at two visits, V1 and V2, 3-24 months apart, to screen for prolonged faecal carriage of ESBL-producing E. coli. Patient clinical information and whole genome sequence of each isolate were used for association studies. RESULTS: A total of 4641 children were sampled. 375 (8%) carried an ESBL-producing Enterobacterales, among which 142 of ESBL-producing E. coli carriers were once again sampled at V2 and included in this study. 21.8% (n = 31/142) and 18.4% (n = 16/99) carried the same ESBL-producing E. coli clone for at least 3 and 6 months, respectively. B2 phylogroup, and among which ST131 clones were associated with an increased risk of persistent carriage. Multivariate analysis identified virulence associated genes involved in adhesion (papC/papGII allele and a tia-like gene) and encoding toxin (senB) as major risk factors for persistence. A genome wide association study highlighted the potential role of the frz metabolic operon, known to be involved in enterocytes adhesion/internalisation. CONCLUSION: Main extraintestinal pathogenic E. coli genomic features (phylogenetic background, adhesion properties) are associated with ESBL-producing E. coli gut colonisation persistence in infants, which could potentially lead to an increased risk of febrile urinary tract infection in these patients.

Child↗

Extensive and differential platinum chemotherapy mutagenesis in livers of children.

Childhood cancer survivors often experience late adverse effects that may be linked to chemotherapy mutagenesis. We studied chemotherapy mutagenesis in normal pediatric tissues using duplex sequencing (NanoSeq) to enable the detection of mutations from single DNA molecules. We found that platinum chemotherapeutics increased the mutation burdens of normal pediatric tissues to levels seen in adults. In the liver, platinum agents imparted a tissue-specific mutational signature that was absent from other tissues. Gene-focused duplex sequencing revealed that chemotherapy mutagenesis generates a great diversity of nonsynonymous variants, some of which may have functional potential, such as leukemogenic variants in blood. Our findings demonstrate extensive chemotherapy mutagenesis in normal tissues of children, which may provide a plausible link between chemotherapy exposure and adverse effects in later life.

Child↗

Clinical and immunological characterization of a child with a homozygous TBK1 kinase-domain truncation.

TBK1 is a serine-tyrosine kinase protein that transmits signals from pattern recognition receptors to the NF-κB pathway leading to production of Type 1 Interferons. Mutations in this protein have been associated with arthritis, vasculitis, herpes simplex encephalitis and amyotrophic lateral sclerosis. In the current study, we characterized the functional consequences of a TBK1-variant bearing a truncation in exon 4 and 5 in a patient with poly arthritis resembling juvenile idiopathic arthritis and necrotizing encephalitis. The truncation was associated with reduced TBK1 protein abundance and altered phosphorylation. The variant was associated with increased basal/and or Poly-I: C induced IL-6, TNFα, IL-1β and IL-18 and type 1 Interferon ex vivo. Our findings expand the phenotypic spectrum of TBK1 loss-of-function variants and may provide insight into the management of immune dysregulation in affected patients.

Child↗