PubMed · 10658406
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M F Collen. Evolution of the user/computer interface: Part I, Data input.. https://pubmed.ncbi.nlm.nih.gov/10658406/
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A software tool, Expression Profile Viewer (ExProView), for analysis of gene expression profiles derived from expressed sequence tags (ESTs) and SAGE (serial analysis of gene expression) is presented. The software visualizes a complete set of classified transcript data in a two-dimensional array of dots, a "virtual chip," in which each dot represents a known gene as characterized in the transcript databases Expressed Gene Anatomy Database or UniGene. The virtual chip display can be changed between representations of different conceptual systems for gene/protein classification and grouping. Four alternative projections are currently available: (i) cellular role, (ii) subcellular compartment, (iii) chromosome localization, and (iv) total UniGene display. However, the chip can be adapted to any other desired layout. By selecting dots, further information about the represented genes is obtained from the local database and WWW links. The software thus provides a visualization of global mRNA expression at the descriptive level and guides in the exploration of patterns of functional expression, while maintaining direct access to detailed information on each individual gene. To evaluate the software, public EST and SAGE gene expression data obtained from the Cancer Genome Anatomy Project at the National Center for Biotechnology Information were analyzed and visualized. A demonstration of the software is available at http://www.biochem.kth. se/exproview/.
A new type of graphical tool for explaining and analyzing magnetic resonance imaging pulse sequences is developed and illustrated. This tool combines the partition diagram, which shows the evolution of multiple echoes with the application of multiple RF pulses, and k-space graphs, which show the evolution of the transverse magnetization as gradients are applied. The strength of the new tool lies in its ability to depict clearly the progression of complex imaging pulse sequences. Several complicated excitation sequences are used to illustrate this method.