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Nodal signalling in vertebrate development.

A F Schier·M M Shen
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Abstract

Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor beta-related signal, is responsible for many of the events that configure the vertebrate embryo. The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control of mesoderm and endoderm formation, the positioning of the anterior-posterior axis, neural patterning and left-right axis specification.

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AnimalsBody PatterningEmbryonic InductionForecastingMesodermNodal ProteinSignal TransductionTransforming Growth Factor betaJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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A F Schier, M M Shen. 2000-01-27. Nodal signalling in vertebrate development.. https://doi.org/10.1038/35000126

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