Fibroblast growth factor and hydrocephalus.

P Cuevas; G Giménez-Gallego

doi:10.1080/01616412.2000.11741043

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PubMed · 10672586

Fibroblast growth factor and hydrocephalus.

P Cuevas·G Giménez-Gallego

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Abstract

The immunohistochemical localization of basic fibroblast growth factor (bFGF) was studied in ventricular ependyma and choroid plexus of aged-matched normotensive and spontaneously hypertensive rats at different ages using a polyclonal antibody against bFGF. The bFGF-like immunoreactivity was observed in brain ependyma and choroid plexus of young and old normotensive rats. However, a progressive loss of immunoreactivity was observed with age in spontaneously hypertensive rats, that was associated with a progressive cerebroventricular dilation. These results show a new neuroendocrine anomaly to be added to the many others previously observed in this rat strain, when they develop hydrocephalus as they age.

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Aging Animals Cerebral Ventricles Choroid Plexus Ependyma Fibroblast Growth Factor 2 Hydrocephalus Hypertension Immunohistochemistry Male Rats Rats, Inbred SHR Rats, Inbred WKY Reference Values Journal Article Research Support, Non-U.S. Gov't

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P Cuevas, G Giménez-Gallego. 2000. Fibroblast growth factor and hydrocephalus.. https://doi.org/10.1080/01616412.2000.11741043

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