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PubMed · 10675910

Unveiling synaptic plasticity: a new graphical and analytical approach.

J D Clements·R A Silver
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Abstract

Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic site. This article describes a new approach that, in its simplest form, can identify the site of expression by direct graphical means. A more-sophisticated form of the technique can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength.

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6-Cyano-7-nitroquinoxaline-2,3-dioneAnesthetics, LocalAnimalsBaclofenCells, CulturedComputer GraphicsData DisplayExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGABA AgonistsLidocaineMathematical ComputingMemoryModels, NeurologicalNeuronal PlasticityNeuronsRatsRegression AnalysisSignal Processing, Computer-AssistedSynapsesJournal ArticleResearch Support, Non-U.S. Gov't

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J D Clements, R A Silver. 2000. Unveiling synaptic plasticity: a new graphical and analytical approach.. https://doi.org/10.1016/s0166-2236(99)01520-9

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