Study of implanted biomaterial functionality by diphosphonate molecules labeled with radioactive 99mTc.

J L Irigaray; H Oudadesse; V Brun; P Labarre; M Rapp; J C Madelmont; J Bonafous

doi:10.1007/bf02784253

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Study of implanted biomaterial functionality by diphosphonate molecules labeled with radioactive 99mTc.

J L Irigaray·H Oudadesse·V Brun·P Labarre·M Rapp·J C Madelmont·J Bonafous

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Abstract

An implanted biomaterial can be transformed into young bone after some months, but it has not necessary reached full biofunctionality. Mineral concentration kinetics and crystal-structure studies, still being carried out in our group, are completed here by biofunctionality determinations. A natural coral is implanted in vivo at the cortical level of the femoral diaphyoff++ in rabbits. Diphosphonates molecules labeled with radioactive 99mTc are then injected in rabbits and the fixation of the radioactivity is analyzed in several sites for 8 mo after the implantation. Nuclear instruments and methods are used for the measurements. Four successive cycles of osseous remodeling are determined before reaching a biofunctional phase.

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Animals Biocompatible Materials Diphosphonates Organotechnetium Compounds Rabbits Journal Article

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J L Irigaray, H Oudadesse, V Brun, P Labarre, M Rapp, J C Madelmont, J Bonafous. 1999. Study of implanted biomaterial functionality by diphosphonate molecules labeled with radioactive 99mTc.. https://doi.org/10.1007/bf02784253

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