PubMed · 10678331
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L French. 2000. Bed rest ineffective as therapy.. https://pubmed.ncbi.nlm.nih.gov/10678331/
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OBJECTIVE: To assess the osteoporotic risk of short-term low-dose heparin plus bedrest in pregnancy. STUDY DESIGN: In a prospective case-control study, 10 pregnant women on bedrest receiving prophylactic unfractionated heparin 10,000 IU per day for 7-46 days pre-study and 28 days per-study were compared with 6 normal pregnant controls of similar maternal and gestational age and 10 nonpregnant women of similar age. Serum ionised calcium, 1,25-dihydroxyvitamin D(3), osteocalcin, and urinary calcium/creatinine ratio were determined three times at 2-week intervals. RESULTS: 1,25-Dihydroxyvitamin D(3) was lower in the treated group than in pregnant controls throughout (P<0.03). Osteocalcin was lower at study start than end in both pregnant groups (P<0.05), and lower in the treated group than in either pregnant (n.s.) or nonpregnant controls (P<0.005). Calcium/creatinine ratio differences were non significant (n.s.). CONCLUSION: Short-term low-dose heparin plus bedrest suppresses 1,25-dihydroxyvitamin D(3) and osteocalcin levels in pregnancy.
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