High-throughput and ultra-high-throughput screening: solution- and cell-based approaches.

S A Sundberg

doi:10.1016/s0958-1669(99)00051-8

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High-throughput and ultra-high-throughput screening: solution- and cell-based approaches.

S A Sundberg

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Abstract

The trend towards assay miniaturization for high-throughput and ultra-high-throughput screening continues to spur development of homogeneous, fluorescence-based assays in higher density, smaller volume microplate formats. Recently, first-generation microfluidic devices have been designed for performing continuous-flow biochemical and cell-based assays. These devices provide orders-of-magnitude reduction in reagent consumption, and offer the potential for implementing high-throughput screening in formats that integrate up-front compound handling with unique assay functionality.

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S A Sundberg. 2000. High-throughput and ultra-high-throughput screening: solution- and cell-based approaches.. https://doi.org/10.1016/s0958-1669(99)00051-8

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