Manipulating the host to study bacterial virulence.

E T Harvill; J F Miller

doi:10.1016/s1369-5274(99)00057-0

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PubMed · 10679424

Manipulating the host to study bacterial virulence.

E T Harvill·J F Miller

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Abstract

The ability to manipulate animal hosts as well as bacterial pathogens greatly expands the utility of in vivo models of infection. For example, the construction of mice that harbor human tissues or express specific transgenes can provide ligand-receptor interactions that are essential for pathogenesis. Interactions between virulence factors and specific host defenses can sometimes be resolved by challenging selectively immuno deficient mice with bacteria containing virulence gene mutations. Transgenic animals expressing inducible reporters can be used to conveniently identify cells in which specific response pathways have been activated during infection. These and other approaches promise to improve the quality of information obtainable from in vivo assessments of pathogenesis.

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Animals Animals, Genetically Modified Bacteria Bacterial Infections Disease Models, Animal Humans Mice Mice, Transgenic Virulence Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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E T Harvill, J F Miller. 2000. Manipulating the host to study bacterial virulence.. https://doi.org/10.1016/s1369-5274(99)00057-0

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