The third tubulin pool.

L Lafanechère; D Job

doi:10.1023/a:1007575012904

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PubMed · 10685599

The third tubulin pool.

L Lafanechère·D Job

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Abstract

Tubulin normally undergoes a cycle of detyrosination/tyrosination on the carboxy terminus of its alpha-subunit and this results in subpopulations of tyrosinated tubulin and detyrosinated tubulin. Brain tubulin preparations also contain a third major tubulin subpopulation which is non-tyrosinatable. This review describes the purification and the structural characterization of non-tyrosinatable tubulin. This tubulin variant lacks a carboxyterminal glutamyl-tyrosine group on its alpha-subunit (delta2-tubulin). Delta2-tubulin is generated from detyrosinated tubulin through an irreversible reaction. Delta2-tubulin accumulates in neurons and in stable microtubule assemblies. It also accumulates in some tumor cells due to the frequent loss of tubulin tyrosine ligase in such cells. Delta2-tubulin may be a useful marker of malignancy in human tumors.

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Biomarkers, Tumor Humans Microtubules Neurons Tubulin Tyrosine Journal Article Review

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L Lafanechère, D Job. 2000. The third tubulin pool.. https://doi.org/10.1023/a%3A1007575012904

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