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PubMed · 10689299

Antigen processing and presentation by intestinal epithelial cells - polarity and complexity.

R M Hershberg·L F Mayer
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Abstract

The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg and colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa

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AnimalsAntigen PresentationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell PolarityEpithelial CellsHistocompatibility Antigens Class IIHumansIntestinal MucosaModels, BiologicalJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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R M Hershberg, L F Mayer. 2000. Antigen processing and presentation by intestinal epithelial cells - polarity and complexity.. https://doi.org/10.1016/s0167-5699(99)01575-3

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