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PubMed · 10689355

Circadian rhythms: new functions for old clock genes.

P L Lakin-Thomas
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Abstract

The mechanisms of circadian clocks, which time daily events, are being investigated by characterizing 'clock genes' that affect daily rhythms. The core of the clock mechanism in Drosophila, Neurospora, mammals and cyanobacteria is described by a transcription-translation feedback-loop model. However, problems with this model could indicate that it is time to look at the functions of these genes in a different light. Our a priori assumptions about the nature of circadian clocks might have restricted our search for new mutants in ways that prevent us from finding important clock genes.

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AcetabulariaAnimalsCircadian RhythmCyanobacteriaDrosophila melanogasterFeedbackGene Expression RegulationGene Expression Regulation, FungalGenes, BacterialGenes, FungalGenes, PlantHumansMammalsMiceModels, BiologicalModels, GeneticMutagenesisNeurospora crassaProtein BiosynthesisProtein Structure, TertiaryTranscription, GeneticJournal ArticleReview

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BibTeXRIS

P L Lakin-Thomas. 2000. Circadian rhythms: new functions for old clock genes.. https://doi.org/10.1016/s0168-9525(99)01945-9

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