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A classical setting for associations between markers and loci affecting quantitative traits.

D M Nielsen·B S Weir
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Abstract

We examine the relationships between a genetic marker and a locus affecting a quantitative trait by decomposing the genetic effects of the marker locus into additive and dominance effects under a classical genetic model. We discuss the structure of the associations between the marker and the trait locus, paying attention to non-random union of gametes, multiple alleles at the marker and trait loci, and non-additivity of allelic effects at the trait locus. We consider that this greater-than-usual level of generality leads to additional insights, in a way reminiscent of Cockerham's decomposition of genetic variance into five terms: three terms in addition to the usual additive and dominance terms. Using our framework, we examine several common tests of association between a marker and a trait.

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AnimalsGenetic MarkersHumansMathematical ComputingModels, GeneticQuantitative Trait, HeritableJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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D M Nielsen, B S Weir. 1999. A classical setting for associations between markers and loci affecting quantitative traits.. https://doi.org/10.1017/s0016672399004231

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