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PubMed · 10694950

Eosinophil ablation and tumor development.

D T Wong·S M Bowen·A Elovic·G T Gallagher·P F Weller
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Abstract

Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate the potential role of the eosinophil in squamous cell carcinoma development and provide an experimental model for future studies. The carcinogen-induced hamster oral cancer model was found to fulfill these objectives. Eosinophils progressively infiltrate into this carcinogen-induced oral cancer model. We now demonstrate that TATE is completely abolished by the use of an anti-interleukin-5 monoclonal antibody (mAb) preparation, TRFK-5. Clinical observations revealed that TRFK-5-treated hamsters exhibited smaller tumor burden and delayed onset of tumor development. The results suggest that anti-interleukin-5 antibody treatment may delay and/or inhibit tumor development, and that eosinophils may have a tumor-promoting role.

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AnimalsAntibodies, MonoclonalCarcinoma, Squamous CellCricetinaeEosinophiliaInterleukin-5MaleMesocricetusMouth NeoplasmsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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D T Wong, S M Bowen, A Elovic, G T Gallagher, P F Weller. 1999. Eosinophil ablation and tumor development.. https://doi.org/10.1016/s1368-8375(99)00023-8

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