Morphology of the designed biodegradable cisplatin microsphere.

S Natsugoe; K Tokuda; M Shimada; T Kumanohoso; M Baba; S Takao; M Tabata; K Nakamura; H Yoshizawa; T Aikou

PubMed · 10697528

Morphology of the designed biodegradable cisplatin microsphere.

S Natsugoe·K Tokuda·M Shimada·T Kumanohoso·M Baba·S Takao·M Tabata·K Nakamura·H Yoshizawa·T Aikou

Abstract

We observed the morphological changes in microspheres containing cisplatin (CDDP) embedded in poly-d,l,-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS). The in vitro release of CDDP from CDDP-PPMS continued for more than four weeks. Scanning electron microscopy revealed that though the particles of CDDP-PPMS were spherical and superficially smooth, small pores with a superficial irregularity appeared six months later. CDDP-PPMS particles were found in the stomata of the omentum after intraperitoneal administration. When CDDP-PPMS was administered after Yoshida sarcoma cells were intraperitoneally transplanted, CDDP-PPMS was observed histologically in the necrotic tissues of the omentum. These experimental results confirmed the release of CDDP from CDDP-PPMS and the histological efficacy of CDDP-PPMS in the omentum against peritoneal metastasis.

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Animals Biocompatible Materials Cisplatin Drug Carriers Male Microscopy, Electron, Scanning Microspheres Omentum Rats Journal Article Research Support, Non-U.S. Gov't

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S Natsugoe, K Tokuda, M Shimada, T Kumanohoso, M Baba, S Takao, M Tabata, K Nakamura, H Yoshizawa, T Aikou. Morphology of the designed biodegradable cisplatin microsphere.. https://pubmed.ncbi.nlm.nih.gov/10697528/

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