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PubMed · 10702680

The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization.

K Lehnert·J Ni·E Leung·S Gough·C M Morris·D Liu·S X Wang·R Langley·G W Krissansen
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Abstract

Herein we report the cloning of cDNAs and incompletely processed hnRNAs from endothelia and heart that encode the alpha10 subunit forming part of the novel collagen type II-binding integrin alpha10beta1 of chondrocytes. Analysis of hnRNA clones and reported expressed sequence tags revealed the positions of 17 putative intron-exon splice junctions shared with those of the p150,95 (ITGAX) gene. Human alpha10 transcripts of 5.4 and 1.8 kb were not restricted to chondrocytes but, instead, were widely expressed in a panel of 24 tissue types, where the highest expression was found in muscle and heart. The human alpha10 subunit gene (ITGA10) was localized to band q21 of chromosome 1.

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Amino Acid SequenceChromosomes, Human, Pair 1Cloning, MolecularConserved SequenceDNA, ComplementaryEndothelium, VascularExonsExpressed Sequence TagsGene Expression ProfilingGene LibraryHumansIn Situ Hybridization, FluorescenceIntegrin alpha ChainsIntegrinsIntronsMolecular Sequence DataMyocardiumPhysical Chromosome MappingRNA, MessengerSequence AlignmentJournal ArticleResearch Support, Non-U.S. Gov't

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K Lehnert, J Ni, E Leung, S Gough, C M Morris, D Liu, S X Wang, R Langley, G W Krissansen. 1999. The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization.. https://doi.org/10.1159/000015434

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