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PubMed · 10708961

TGF-beta in blood: a complex problem.

D J Grainger·D E Mosedale·J C Metcalfe
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Abstract

The cytokine transforming growth factor-beta (TGF-beta) was initially purified from human platelets, a rich source of this protein. In addition to platelets, TGF-beta1 is also found in other blood fractions, including plasma and the circulating leukocytes. However, more than 15 years after the initial isolation of TGF-beta1, there remains no consensus on how much TGF-beta1 is present in normal human plasma. Here we review the difficulties associated with measuring TGF-beta concentrations in complex biological fluids, and discuss the current state of knowledge on the distribution of TGF-beta isoforms in various blood fractions as well as the nature of the TGF-beta-containing protein complexes.

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AnimalsBlood PlateletsChromatography, LiquidEnzyme-Linked Immunosorbent AssayHumansReference ValuesTransforming Growth Factor betaJournal ArticleReview

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D J Grainger, D E Mosedale, J C Metcalfe. TGF-beta in blood: a complex problem.. https://doi.org/10.1016/s1359-6101(99)00037-4

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