PU.1 expression in microglia.

M R Walton; H Gibbons; G A MacGibbon; E Sirimanne; J Saura; P D Gluckman; M Dragunow

doi:10.1016/s0165-5728(99)00262-3

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PubMed · 10713349

PU.1 expression in microglia.

M R Walton·H Gibbons·G A MacGibbon·E Sirimanne·J Saura·P D Gluckman·M Dragunow

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Abstract

The transcription factor PU.1 has a pivotal role in both the generation and function of macrophages. To determine whether PU.1 is also involved in microglial regulation, we investigated its expression following hypoxic-ischemia (HI) brain injury and in the BV-2 microglial cell line. We found that microglia constitutively expressed high levels of PU.1 protein in both their 'resting' and 'activated' states.

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Animals Blotting, Western Brain Cell Line Hypoxia-Ischemia, Brain Immunohistochemistry Microglia Proto-Oncogene Proteins Rats Rats, Wistar Time Factors Trans-Activators Up-Regulation Proto-Oncogene Protein Spi-1 Journal Article Research Support, Non-U.S. Gov't

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M R Walton, H Gibbons, G A MacGibbon, E Sirimanne, J Saura, P D Gluckman, M Dragunow. 2000-05-01. PU.1 expression in microglia.. https://doi.org/10.1016/s0165-5728(99)00262-3

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