Invariance vs variability in aphasic performance. An example: agrammatism.

We identified areas of the brain that are critical for naming pictures of objects, using a new methodology for testing which components of a network of brain regions are essential for that task. We identified areas of hypoperfusion and structural damage with magnetic resonance perfusion- and diffusion-weighted imaging immediately after stroke in 87 individuals with impaired picture naming. These individuals were reimaged after 3-5 d, after a subset of patients underwent intervention to restore normal blood flow, to determine areas of the brain that had reperfused. We identified brain regions in which reperfusion was associated with improvement in picture naming. Restored blood flow to left posterior middle temporal/fusiform gyrus, Broca's area, and/or Wernicke's area accounted for most acute improvement after stroke. Results show that identifying areas of reperfusion that are associated with acute improvement of a function can reveal the brain regions essential for that function.

Aphasia, Broca↗

PubMed2006

Lexical and post-lexical phonological representations in spoken production.

Theories of spoken word production generally assume a distinction between at least two types of phonological processes and representations: lexical phonological processes that recover relatively arbitrary aspects of word forms from long-term memory and post-lexical phonological processes that specify the predictable aspects of phonological representations. In this work we examine the spoken production of two brain-damaged individuals. We use their differential patterns of accuracy across the tasks of spoken naming and repetition to establish that they suffer from distinct deficits originating fairly selectively within lexical or post-lexical processes. Independent and detailed analyses of their spoken productions reveal contrasting patterns that provide clear support for a distinction between two types of phonological representations: those that lack syllabic and featural information and are sensitive to lexical factors such as lexical frequency and neighborhood density, and those that include syllabic and featural information and are sensitive to detailed properties of phonological structure such as phoneme frequency and syllabic constituency.

Aphasia, Broca↗

PubMed2006

Aphasia and leg weakness.

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Aphasia, Broca↗