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PubMed · 10717543

Telomeres and HIV disease.

R B Effros
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Abstract

Telomere measurement, envisioned as a novel approach to elucidate T-cell dynamics in HIV disease, failed to reveal any consistent pattern in CD4+ T cells. By contrast, significant telomere shortening, as well as other hallmarks suggestive of replicative senescence, was observed within the CD8+ T-cell subset. Telomere studies have thus provided unanticipated insight into a novel facet of memory CD8+ T lymphocyte dynamics that may explain the exhaustion of the protective antiviral immune response. Strategies aimed at manipulating replicative senescence, therefore, offer unique approaches to immune reconstitution.

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CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHIV InfectionsHumansTelomereJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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R B Effros. 2000. Telomeres and HIV disease.. https://doi.org/10.1016/s1286-4579(00)00283-5

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