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[Multi-sequential arterial chemoembolization of advanced hepatocellular carcinomas: computerized tomography follow-up parameters for evaluating effectiveness of therapy].

T J Vogl·H Schroeder·M Trapp·R Straub·A Schuster·M Schuster·M Mack·F Souchon·P Neuhaus
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Abstract

PURPOSE: An evaluation of clinical and computed tomography parameters for the transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). MATERIAL AND METHODS: Retro- and prospective analysis of 123 TACE procedures in 37 patients (mean age: 63.3 years). RESULTS: Overall mean survival rate for all treated patients was 785 days with a mean value of 387 days. The 1 year survival rate was 62%. Quantitative tumor volumetry revealed a significant difference in survival rate with a mean value of 678 days for patients with a reduction of tumor volume between 0 and 50%, 976 days for a volume reduction of 51-100% and 277 days for an increase in tumor volume during therapy. Patients with a high lipiodol retention presented improved survival data (902 days) versus patients with a low lipiodol retention (513 days). Homogeneous retention of lipiodol was a positive factor on survival as compared to an inhomogenous form of retention. CONCLUSION: In patients with a positive therapy response after TACE the prognosis can be improved by repeated embolization.

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AgedCarcinoma, HepatocellularChemoembolization, TherapeuticCisplatinCombined Modality TherapyDoxorubicinFemaleFollow-Up StudiesHumansInfusions, Intra-ArterialIodized OilLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalSurvival RateTomography, X-Ray ComputedTreatment OutcomeJournal Article

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T J Vogl, H Schroeder, M Trapp, R Straub, A Schuster, M Schuster, M Mack, F Souchon, P Neuhaus. 2000. [Multi-sequential arterial chemoembolization of advanced hepatocellular carcinomas: computerized tomography follow-up parameters for evaluating effectiveness of therapy].. https://doi.org/10.1055/s-2000-279

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