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Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI.

M Cercignani·G Iannucci·M A Rocca·G Comi·M A Horsfield·M Filippi
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Abstract

OBJECTIVE: To compare diffusion characteristics of MS lesions, normal-appearing white matter (NAWM) from patients, and normal white matter from control subjects, and to investigate the correlations between the magnetization transfer ratio (MTR) and a directionally averaged tissue water diffusion coefficient (D) in patients. BACKGROUND: MS and other pathologic processes that modify tissue integrity can result in abnormal diffusion of water molecules detectable by diffusion-weighted imaging (DWI). METHODS: Conventional dual-echo and DWI scans were obtained from 35 patients with relapsing-remitting MS and 24 healthy control subjects. MT scans were also obtained from the patients. After coregistration of all scans, MTR and D values from MS lesions and NAWM in different regions were marked using the dual-echo scans as a reference. D values from the same brain regions in control subjects were acquired. Histograms of MTR and D were also produced. RESULTS: Patients with MS had significantly higher D values in all the areas studied. Moreover, histogram metrics (peak height, peak site, and average D) from patients were substantially different from those of control subjects. In patients, average lesion D and MTR were markedly different from those in the NAWM. There was an inverse correlation between average lesion MTR and D inside lesions, whereas no correlation was found for average MTR and D taken from the histograms. CONCLUSIONS: DWI detects severe tissue disruption inside lesions and subtle widespread abnormalities in NAWM in patients with relapsing-remitting MS. MT and DWI may provide information about different aspects of brain pathology in MS.

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AdultBrainFemaleHumansMagnetic Resonance ImagingMaleMultiple SclerosisJournal ArticleResearch Support, Non-U.S. Gov't

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M Cercignani, G Iannucci, M A Rocca, G Comi, M A Horsfield, M Filippi. 2000-03-14. Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI.. https://doi.org/10.1212/wnl.54.5.1139

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