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PubMed · 10723032

Checkpoints controlling mitosis.

D J Clarke·J F Giménez-Abián
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Abstract

Each year many reviews deal with checkpoint control.((1-5)) Here we discuss checkpoint pathways that control mitosis. We address four checkpoint systems in depth: budding yeast DNA damage, the DNA replication checkpoint, the spindle assembly checkpoint and the mammalian G2 topoisomerase II-dependent checkpoint. A main focus of the review is the organization of these checkpoint pathways. Recent work has elucidated the order-of-function of several checkpoint components, and has revealed that the S phase, DNA damage and spindle assembly checkpoints each have at least two parallel branches. These steps forward have largely come from kinetic studies of checkpoint-defective mutants.

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Adaptation, PhysiologicalAnimalsDNA DamageDNA Topoisomerases, Type IIHumansMitosisS PhaseSignal TransductionSpindle ApparatusJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Review

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D J Clarke, J F Giménez-Abián. 2000. Checkpoints controlling mitosis.. https://doi.org/10.1002/(sici)1521-1878(200004)22%3A4%3C351%3A%3Aaid-bies5%3E3.0.co%3B2-w

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