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Genetic control of the immune response to mammalian chymotrypsins in mice. II. The immune response to low doses of bovine alpha-chymotrypsin.

C R Young
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Abstract

The immune response to the antigen bovine pancreatic alpha-chymotrypsin was investigated in ten recombinant strains of mice. Using a fixed antigen-percentage bound isotope technique, it was found that the quantity of antibody produced was related to the H-2 haplotype of the responding animal. A continuous distribution for the mean antibody responses was obtained for the ten strains of mice. High responsiveness was associated with the H-2 haplotype gamma2. The genetic control of the immune response to this immunogen was found to be both quantitative and qualitative.

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AnimalsAntibody FormationCattleChymotrypsinDose-Response Relationship, ImmunologicGenes, MHC Class IIGenotypeImmunologic MemoryMiceMice, Inbred StrainsRabbitsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

C R Young. 1979. Genetic control of the immune response to mammalian chymotrypsins in mice. II. The immune response to low doses of bovine alpha-chymotrypsin.. https://doi.org/10.1111/j.1744-313x.1979.tb00676.x

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