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PubMed · 10725905

How Echinococcus granulosus deals with complement.

A M Ferreira·F Irigoín·M Breijo·R B Sim·A Diáz
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Abstract

Here, Ana Mar a Ferreira and colleagues discuss the interplay between the larval stages of Echinococcus granulosus and an important effector arm of immunity: the host complement system. During early infection, the parasite activates complement, and hence complement-dependent inflammatory responses. However, on differentiation into the hydatid cyst, the parasite exposes to the host a structure - the cyst wall - that does not activate complement strongly. Mechanisms inhibiting complement activation on the cyst wall have been elucidated, contributing to the understanding of how this large, persistent, tissue-dwelling pathogen controls the inflammatory response.

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AnimalsCattleComplement ActivationEchinococcosisEchinococcusHost-Parasite InteractionsMiceJournal ArticleResearch Support, Non-U.S. Gov'tReview

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A M Ferreira, F Irigoín, M Breijo, R B Sim, A Diáz. 2000. How Echinococcus granulosus deals with complement.. https://doi.org/10.1016/s0169-4758(99)01625-7

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