Improved controlled release study of lomustine.

Y Sun; H Zhou; Q Zhang; X Wu

doi:10.3109/10731190009118579

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Improved controlled release study of lomustine.

Y Sun·H Zhou·Q Zhang·X Wu

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Abstract

Lomustine (CCNU) microcapsules was prepared by improved recoacervation method, then mixed microcapsules with 0.7% collagen swelling solution to prepare the emulsion, spreaded the emulsion on the plate to form membrane and cross-linked it, the membrane would be planted into body and was expected to release at steady speed. The concentration of CCNU and the CCNU content of microcapsules were measured by ultraviolet spectrophotometry to observe the release of CCNU be slow and constant, approach to 0-class release approximately.

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Absorbable Implants Antineoplastic Agents, Alkylating Buffers Capsules Collagen Delayed-Action Preparations Drug Compounding Lomustine Time Factors Journal Article Research Support, Non-U.S. Gov't

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Y Sun, H Zhou, Q Zhang, X Wu. 2000. Improved controlled release study of lomustine.. https://doi.org/10.3109/10731190009118579

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