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The thymus and central tolerance.

H Kishimoto·J Sprent
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Abstract

T cell tolerance to self-components occurs largely in the thymus during early differentiation and leads to death (negative selection) of T cells with overt autoreactivity. In this article we review the evidence that negative selection in mice occurs mainly in the medulla at the level of a population of semimature T cells. The role of Fas and several costimulatory molecules on negative selection and the inhibitory role of certain cytokines are discussed.

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AnimalsApoptosisCerebral CortexImmune ToleranceMiceThymus GlandJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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H Kishimoto, J Sprent. 2000. The thymus and central tolerance.. https://doi.org/10.1006/clim.1999.4818

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