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PubMed · 10735147

Atypical neuroleptics.

J P Pandarakalam
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Abstract

The discovery that clozapine alleviates both positive and negative symptoms of schizophrenia has resulted in the emergence of newer atypical neuroleptics. Even though they are more expensive than traditional antipsychotics they have distinct and important advantages, which may influence the extent of the patient's rehabilitation and compliance.

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Antipsychotic AgentsCholinergic AntagonistsDrug InteractionsFemaleHumansMaleReceptors, Dopamine D2SchizophreniaSubstantia NigraTreatment RefusalVentral Tegmental AreaJournal ArticleReview

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BibTeXRIS

J P Pandarakalam. 2000. Atypical neuroleptics.. https://doi.org/10.12968/hosp.2000.61.1.1266

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PubMed2007

Differential pharmacology of atypical antipsychotics: clinical implications.

PURPOSE: Pharmacology of atypical antipsychotics and the clinical implications are reviewed. SUMMARY: Psychiatric disorders, such as schizophrenia and bipolar disorder, are often associated with poor outcomes. Atypical antipsychotics have become the standard of care for these disorders, and multiple agents have demonstrated efficacy for both acute and maintenance therapy. As a result of their differential pharmacologic properties, atypical antipsychotics have diverse clinical profiles, resulting in different liabilities for specific adverse events. These effects can, in turn, have an adverse impact on patient functionality, adherence to therapy, and overall health. CONCLUSION: Atypical antipsychotics have distinct pharmacological profiles which result in clinically meaningful differences in adverse effects. Clinicians should have a wide choice of agents available with which to optimize outcomes in the majority of patients with psychiatric disorders.

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