Nuclear chaperones.

A Philpott; T Krude; R A Laskey

doi:10.1006/scdb.1999.0346

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Nuclear chaperones.

A Philpott·T Krude·R A Laskey

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Abstract

We discuss nuclear chaperones that bind correctly folded protein subunits and mediate molecular interactions, particularly between proteins and nucleic acids. The charge of these chaperones helps to prevent non-specific electrostatic interactions between the components. Thus, an ordered assembly of macromolecular complexes is mediated, most notably in the formation and maintenance of chromatin, though similar principles are likely to apply in ribonucleoprotein assembly. Here, we discuss roles for nuclear chaperones in mediating nucleosome assembly and remodelling during DNA replication and transcription, and upon fertilisation.

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Animals Chromatin Humans Macromolecular Substances Models, Biological Molecular Chaperones Nuclear Proteins Nucleoplasmins Nucleoproteins Phosphoproteins Journal Article Research Support, Non-U.S. Gov't Review

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A Philpott, T Krude, R A Laskey. 2000. Nuclear chaperones.. https://doi.org/10.1006/scdb.1999.0346

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