Linking Hebb's coincidence-detection to memory formation.

J Z Tsien

doi:10.1016/s0959-4388(00)00070-2

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Linking Hebb's coincidence-detection to memory formation.

J Z Tsien

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Abstract

The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.

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Animals Behavior, Animal Learning Long-Term Potentiation Memory Mice Mice, Knockout Mice, Neurologic Mutants Models, Neurological Neuronal Plasticity Receptors, N-Methyl-D-Aspartate Time Perception Journal Article Review

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J Z Tsien. 2000. Linking Hebb's coincidence-detection to memory formation.. https://doi.org/10.1016/s0959-4388(00)00070-2

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