Effective energy functions for protein structure prediction.

T Lazaridis; M Karplus

doi:10.1016/s0959-440x(00)00063-4

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Effective energy functions for protein structure prediction.

T Lazaridis·M Karplus

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Abstract

Protein structure prediction, fold recognition, homology modeling and design rely mainly on statistical effective energy functions. Although the theoretical foundation of such functions is not clear, their usefulness has been demonstrated in many applications. Molecular mechanics force fields, particularly when augmented by implicit solvation models, provide physical effective energy functions that are beginning to play a role in this area.

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Animals Entropy Humans Models, Chemical Protein Conformation Protein Folding Solvents Thermodynamics Vibration Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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T Lazaridis, M Karplus. 2000. Effective energy functions for protein structure prediction.. https://doi.org/10.1016/s0959-440x(00)00063-4

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