[Endothelium-derived hyperpolarizing factor].

C Brăiloiu; C Beşchea-Chiriac; M Chiriac

PubMed · 10756843

[Endothelium-derived hyperpolarizing factor].

Abstract

Endothelial cells control the tone of the underlying smooth muscle by releasing relaxing factors, such as nitric oxide (NO), prostacycline, endothelium-derived hyperpolarizing factor (EDHF) and contracting factors such as thromboxane A2, endothelins, endoperoxides and superoxide anion. The term EDHF should be restricted to a relaxing factor(s) that differs from NO and prostacyclin. The nature of EDHF is as yet unknown. EDHF might be a cytochrome P-450 metabolite of arachidonic acid or an endogenous cannabinoid--anandamide. The EDHF component of the relaxation is more important in smaller than larger arteries. In various models of disease and in aging animals endothelium-dependent hyperpolarization is diminished. The identification of EDHF and the understanding of its physiological role could lead to the design of new therapies în several cardiovascular diseases.

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Animals Arachidonic Acid Arachidonic Acids Biological Factors Cannabinoids Cytochrome P-450 Enzyme System Endocannabinoids Endothelium, Vascular Nitric Oxide Polyunsaturated Alkamides Vasodilation Journal Article Review

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C Brăiloiu, C Beşchea-Chiriac, M Chiriac. [Endothelium-derived hyperpolarizing factor].. https://pubmed.ncbi.nlm.nih.gov/10756843/

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