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DNA hybridization sensor utilizing [Os(5,6-dmphen)3]2+ by square wave voltammetry.

K Maruyama·J Motonaka·Y Mishima·Y Nakabayashi
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Abstract

DNA hybridization detection utilizing [Os(5,6-dmphen)3]2+ (tris(5,6-dimethyl-phenanthroline) osmium(II/III)) as hybridization indicator was studied, because [Os(5,6-dmphen)3]2+ has the most largest association constant (K2+) and high current density in osmium methyl substituted phenanthroline complexes. As the result, target DNA could be detected selectively ranging from 6.9 x 10(-10) to 6.9 x 10(-5) g/mL using square wave voltammetry.

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Base SequenceDNADNA, Single-StrandedElectrochemistryElectrodesIndicators and ReagentsNucleic Acid HybridizationOligodeoxyribonucleotidesOligonucleotide ProbesOrganometallic CompoundsJournal Article

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K Maruyama, J Motonaka, Y Mishima, Y Nakabayashi. 1999. DNA hybridization sensor utilizing [Os(5,6-dmphen)3]2+ by square wave voltammetry.. https://doi.org/10.1093/nass%2F42.1.181

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