Proteins binding to duplexed RNA: one motif, multiple functions.

I Fierro-Monti; M B Mathews

doi:10.1016/s0968-0004(00)01580-2

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PubMed · 10782096

Proteins binding to duplexed RNA: one motif, multiple functions.

I Fierro-Monti·M B Mathews

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Abstract

Highly structured and double-stranded (ds) RNAs are adaptable and potent biochemical entities. They interact with dsRNA-binding proteins (RBPs), the great majority of which contain a sequence called the dsRNA-binding motif (dsRBM). This approximately 70-amino-acid sequence motif forms a tertiary structure that interacts with dsRNA, with partially duplexed RNA and, in some cases, with RNA-DNA hybrids, generally without obvious RNA sequence specificity. At least nine families of functionally diverse proteins contain one or more dsRBMs. The motif also participates in complex formation through protein-protein interactions.

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Amino Acid Motifs Amino Acid Sequence Molecular Sequence Data Protein Conformation RNA-Binding Proteins Sequence Homology, Amino Acid Journal Article Research Support, U.S. Gov't, P.H.S.Review

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I Fierro-Monti, M B Mathews. 2000. Proteins binding to duplexed RNA: one motif, multiple functions.. https://doi.org/10.1016/s0968-0004(00)01580-2

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