How to activate p53.

T Caspari

doi:10.1016/s0960-9822(00)00439-5

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PubMed · 10801407

How to activate p53.

T Caspari

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Abstract

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

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Ataxia Telangiectasia Mutated Proteins Binding Sites Cell Cycle Proteins Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage DNA-Binding Proteins Humans Nuclear Proteins Phosphorylation Protein Kinases Protein Serine-Threonine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53 Tumor Suppressor Proteins Journal Article Review

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T Caspari. 2000-04-20. How to activate p53.. https://doi.org/10.1016/s0960-9822(00)00439-5

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