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Flavonoids can replace alpha-tocopherol as an antioxidant.

F A van Acker·O Schouten·G R Haenen·W J van der Vijgh·A Bast
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Abstract

Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase. The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes.

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AnimalsAntioxidantsFlavanonesFlavonoidsFlavonolsGlutathioneHydroxyethylrutosideLipid PeroxidationMaleMicrosomes, LiverRatsRats, WistarVitamin EJournal Article

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BibTeXRIS

F A van Acker, O Schouten, G R Haenen, W J van der Vijgh, A Bast. 2000-05-12. Flavonoids can replace alpha-tocopherol as an antioxidant.. https://doi.org/10.1016/s0014-5793(00)01517-9

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