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PubMed · 10821379

Blood coagulation.

B Dahlbäck
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Abstract

Under normal circumstances, the coagulation system is balanced in favour of anticoagulation. Thrombin is the key effector enzyme of the clotting cascade. Antagonists of vitamin K inhibit a vitamin-K-dependent post-translational modification of several coagulation proteins, which is required for these proteins to attain a phospholipid-binding conformation. Heparin stimulates the activity of antithrombin, a serine-protease inhibitor. Analysis of knock-out mice has shown the relative importance of the coagulation factors in vivo. Gene therapy may soon be a therapeutic option for inherited deficiencies of factors VIII and IX.

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AnimalsBlood CoagulationHemophilia AHemophilia BHemorrhagic DisordersHumansProtein CProtein SThrombinVenous Thrombosisvon Willebrand DiseasesJournal ArticleReview

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BibTeXRIS

B Dahlbäck. 2000-05-06. Blood coagulation.. https://doi.org/10.1016/s0140-6736(00)02225-x

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