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PubMed · 1082240

SPLEEN/PATHOL.

R M Bukowski·S Noguchi·J S Hewlett·S Deodhar
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Abstract

Lymphocyte subpopulations were studied in the peripheral blood, lymph nodes, and spleens in a group of 17 patients with untreated Hodgkin's disease. In 12 of 15 cases, diminished absolute levels of T-lymphocytes in the peripheral blood were found; however, this was correlated with total lymphopenia. No direct relationship between "T-lymphopenia" and diminished cellular immunity, as measured by phytohemagglutinin and pokeweed mitogen blast transformation, and delayed cutaneous hypersensitivity was demonstrated. In eight lymph nodes involved histologically by Hodgkin's disease, a preponderance of T-lymphocytes was found when compared with a group of seven hyperplastic nodes (78.2 +/- 8.9% versus 54.5 +/- 11.0%, P is less than 0.01). These latter data appear to be consistent with the hypothesis that the pathogenesis of Hodgkin's disease involves a cell-mediated immune response to a neoplastic (antigenic) element.

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B-LymphocytesHodgkin DiseaseHumansHyperplasiaHypersensitivity, DelayedImmunity, CellularLectinsLeukocyte CountLymph NodesLymphocyte ActivationMitogensSpleenT-LymphocytesComparative StudyJournal Article

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R M Bukowski, S Noguchi, J S Hewlett, S Deodhar. 1976. SPLEEN/PATHOL.. https://pubmed.ncbi.nlm.nih.gov/1082240/

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