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PubMed · 10824312

Pretty reflections.

D E Haley
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Cocaine-Related DisordersHistory, 20th CenturyHumansInterpersonal RelationsSelf-AssessmentAutobiographyBiographyHistorical ArticleJournal Article

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D E Haley. 2000. Pretty reflections.. https://doi.org/10.1353/lm.2000.0005

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PubMed2001

Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.

A series of new N-substituted derivatives of morphinan was synthesized and their binding affinity for the three opioid receptors (mu, delta, and kappa) was determined. A paradoxical effect of N-propargyl (MCL-117) and N-(3-iodoprop-(2E)-enyl) (MCL-118) substituents on the binding affinities for the mu and kappa opioid receptors was observed. All of these novel derivatives showed a preference for the mu and kappa versus delta binding.

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