Time-dependent closed form solutions for fully competitive enzyme reactions.

S Schnell; C Mendoza

doi:10.1006/bulm.1999.0156

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PubMed · 10824432

Time-dependent closed form solutions for fully competitive enzyme reactions.

S Schnell·C Mendoza

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Abstract

An analytic formalism developed earlier to describe the time evolution of the basic enzyme reaction is extended to fully competitive systems. Time-dependent closed form solutions are derived for the three nominal cases of competition: even, slow and fast inhibitors, allowing for the first time the complete characterization of the reactions. In agreement with previous work, the time-independent Michaelis-Menten approach is shown to be inaccurate when a fast inhibitor is present. The validity of the quasi-steady-state approximation on which the present framework is based is also revised.

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Enzyme Inhibitors Enzymes Kinetics Models, Chemical Time Factors Journal Article Research Support, Non-U.S. Gov't

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S Schnell, C Mendoza. 2000. Time-dependent closed form solutions for fully competitive enzyme reactions.. https://doi.org/10.1006/bulm.1999.0156

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