[Causative agents for lung carcinogenesis].

S Yano; S Sone

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PubMed · 10824542

[Causative agents for lung carcinogenesis].

S Yano·S Sone

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Abstract

Lung cancer is a leading cause of malignancy-related death in Japan, and its incidence is still rising steeply. Various factors, including cigarette smoking, asbestos, and diet, have been reported to correlate with the development of lung cancer. Of these factors, cigarette smoking is believed as the major carcinogen for lung cancer. Recent studies indicate that cigarette smoke carcinogens cause genetic damages at both oncogenes(K-ras) and tumor suppressor genes(p53) of lung cancer, and hence initiate and promote the development of lung cancer. This article reviews recent advances in the molecular mechanisms of lung cancer carcinogenesis.

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Air Pollution Asbestos Cholesterol, Dietary Genes, p53 Genes, ras Humans Lung Neoplasms Risk Factors Smoking English Abstract Journal Article Review

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S Yano, S Sone. 2000. [Causative agents for lung carcinogenesis].. https://pubmed.ncbi.nlm.nih.gov/10824542/

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