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Interleukin 16: implications for CD4 functions and HIV-1 progression.

D M Center·H Kornfeld·T C Ryan·W W Cruikshank
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Abstract

In this article, David Center and colleagues clarify the controversies that have emerged over the unique structure of interleukin 16 and its anti-HIV-1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions.

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AnimalsBinding SitesCD4 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDimerizationDisease ProgressionHIV InfectionsHIV-1HomeostasisHumansInflammationInterleukin-16LigandsLymphocyte ActivationMiceModels, MolecularProtein BindingProtein ConformationProtein Structure, TertiaryReceptors, Antigen, T-CellRecombinant Fusion ProteinsJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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D M Center, H Kornfeld, T C Ryan, W W Cruikshank. 2000. Interleukin 16: implications for CD4 functions and HIV-1 progression.. https://doi.org/10.1016/s0167-5699(00)01629-7

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