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PubMed · 10826993

Left-right axis malformations in man and mouse.

B Casey·B P Hackett
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Abstract

The study of left-right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left-right axis formation. Recently, the roles of the TGF-beta family, Sonic hedgehog and fibroblast growth factor signaling, homeobox genes, and cilia in left-right axis determination have been more clearly defined. The identification of genes and environmental factors affecting left-right axis formation has important implications for understanding human laterality defects.

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AnimalsEmbryonic InductionFibroblast Growth FactorsGenes, HomeoboxHedgehog ProteinsHumansMiceProteinsSitus InversusTrans-ActivatorsTransforming Growth Factor betaJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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B Casey, B P Hackett. 2000. Left-right axis malformations in man and mouse.. https://doi.org/10.1016/s0959-437x(00)00085-x

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