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PubMed · 10830734

Syndecans and the lymphoid system.

L Kopper·A Sebestyén
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Abstract

Syndecans, transmembrane proteoglycans, play an important role in cell-matrix and cell-cell interactions, as well as modulators in receptor activation. These functions are partly non-specific and related to the heparan sulfate chains attached to the ectodomain, and partly specific due to the transmembrane and cytoplasmic domains of the core protein. In hemopoietic cells syndecan-1 is expressed only in B cells at certain differentiation stages (pre-B and plasma cells). In lymphoproliferative conditions this selective expression is retained in myelomas/plasmacytomas and other lymphoplasmacytic NHL subtypes, and primary effusional lymphomas. It is probably gained in B-CLL, and lost in other NHLs of pre- or post-follicular origin. It is concluded from these empiric results that the expression of syndecan is essential for some NHLs, probably ensuring the required connections to the microenvironment. From a diagnostic point of view, syndecan-1 is a very useful phenotypic marker to indentify cells with plasmacytic differentiation. The importance of syndecan expression in CLL and Hodgkin's lymphoma still requires further studies.

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ADAM ProteinsADAM12 ProteinAnimalsB-LymphocytesBiomarkers, TumorCell AdhesionCell CommunicationCell DifferentiationChromosomes, Human, Pair 2CytokinesExtracellular MatrixGene Expression RegulationHumansInterleukin-6Lymphoid TissueLymphomaLymphoproliferative DisordersMacromolecular SubstancesMembrane GlycoproteinsMembrane ProteinsMetalloendopeptidasesNeoplasm InvasivenessNeoplasm ProteinsPlasmacytomaProtein ConformationProteoglycansReceptors, CytokineRecombinant Fusion ProteinsSignal TransductionSyndecan-1SyndecansTransfectionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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L Kopper, A Sebestyén. 2000. Syndecans and the lymphoid system.. https://doi.org/10.3109/10428190009087018

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