Decrease in the nucleo-cytoplasmic volume ratio of rabbit spinal ganglion neurons with age.

M Ledda; L Barni; L Altieri; E Pannese

doi:10.1016/s0304-3940(00)01116-2

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Decrease in the nucleo-cytoplasmic volume ratio of rabbit spinal ganglion neurons with age.

M Ledda·L Barni·L Altieri·E Pannese

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Abstract

Nuclear and perikaryal volumes, as well as the mean percentage of perikaryal volume occupied by lipofuscin, were estimated in spinal ganglion neurons of 12, 42 and 79 month-old rabbits. The volume ratio between nucleus and perikaryal cytoplasm (N/C volume ratio) decreased progressively and significantly with increasing age. This was not a consequence of the perikaryal enlargement due to the age-related lipofuscin accumulation since the same result was obtained when the volume occupied by lipofuscin was subtracted from the perikaryal volume. The decrease in the N/C volume ratio may depend on an age-related loss of DNA, a cytoplasmic influence on nuclear size, or other unknown causes.

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Aging Animals Cell Nucleus Cytoplasm Female Ganglia, Spinal Lipofuscin Male Neurons Rabbits Journal Article

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M Ledda, L Barni, L Altieri, E Pannese. 2000-06-09. Decrease in the nucleo-cytoplasmic volume ratio of rabbit spinal ganglion neurons with age.. https://doi.org/10.1016/s0304-3940(00)01116-2

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