[Nitrogen monoxide and nociceptive processes].

S V Kul'chitskiĭ; N V Akulich

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PubMed · 10832413

[Nitrogen monoxide and nociceptive processes].

S V Kul'chitskiĭ·N V Akulich

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Abstract

Experiments on conscious rats studied the effects of systemic or central application of a nitric oxide (NO) donor or NO-synthase inhibitor on the pain sensitivity threshold. Injection of SNAP in doses of 0.2, 2.0, and 20.0 micrograms into the subarachnoidal space of the ventral medulla through a preimplanted steel cannula was accompanied by a dose-dependent change in tail-flick latency. Intraperitoneal injection of 30 mg L-NAME also increased pain sensitivity threshold levels. The findings suggest that the decrease in pain sensitivity after systemic NO-synthase inhibitor administration is due to the modulation of NO-dependent processes at both the central and peripheral levels.

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Animals Body Temperature Dose-Response Relationship, Drug Enzyme Inhibitors Nitric Oxide Nitric Oxide Donors Nitric Oxide Synthase Nociceptors Pain Threshold Rats Rats, Wistar Time Factors English Abstract Journal Article Research Support, Non-U.S. Gov't

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S V Kul'chitskiĭ, N V Akulich. 2000. [Nitrogen monoxide and nociceptive processes].. https://pubmed.ncbi.nlm.nih.gov/10832413/

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