PubMed Health⌕ Search

PubMed · 10847865

Continuous quality improvement efforts decrease postoperative ileus rates.

Abstract

This article describes a continuous quality improvement team's efforts to reduce the number of patients at risk for developing a postoperative ileus. This study was limited to patients who underwent a surgical procedure that did not involve the bowel. Patients who developed an ileus after the surgical procedure (study group) were compared with patients who did not develop an ileus after the same procedure (control group). Principal factors associated with a postoperative ileus included a low serum albumin level, excessive use of narcotics, and a history of a previous gastrointestinal condition. Practice changes were made as a result of these findings. A follow-up chart review revealed a decrease in the postoperative ileus rate.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J Bromenshenkel, M Newcomb, J Thompson. Continuous quality improvement efforts decrease postoperative ileus rates.. https://doi.org/10.1111/j.1945-1474.2000.tb00107.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Partial agonistic action of endomorphins in the mouse spinal cord.

The partial agonistic properties of endogenous mu-opioid peptides endomorphin-1 and endomorphin-2 for G-protein activation were determined in the mouse spinal cord, monitoring the increases in guanosine-5'-o-(3-[35S]thio)triphosphate binding. The G-protein activation induced by endogenous opioid peptide beta-endorphin in the spinal cord was significantly, but partially, attenuated by co-incubation with endomorphin-1 or endomorphin-2. The data indicates that endomorphin-1 and endomorphin-2 are endogenous partial agonists for mu-opioid receptor in the mouse spinal cord.

Analgesics, Opioid↗

Gene expression following acute morphine administration.

The long-term response to neurotropic drugs depends on drug-induced neuroplasticity and underlying changes in gene expression. However, alterations in neuronal gene expression can be observed even following single injection. To investigate the extent of these changes, gene expression in the medial striatum and lumbar part of the spinal cord was monitored by cDNA microarray following single injection of morphine. Using robust and resistant linear regression (MM-estimator) with simultaneous prediction confidence intervals, we detected differentially expressed genes. By combining the results with cluster analysis, we have found that a single morphine injection alters expression of two major groups of genes, for proteins involved in mitochondrial respiration and for cytoskeleton-related proteins. RNAs for these proteins were mostly downregulated both in the medial striatum and in lumbar part of the spinal cord. These transitory changes were prevented by coadministration of the opioid antagonist naloxone. Data indicate that microarray analysis by itself is useful in describing the effect of well-known substances on the nervous system and provides sufficient information to propose a potentially novel pathway mediating its activity.

Analgesics, Opioid↗