Rox1 mediated repression. Oxygen dependent repression in yeast.

A J Kastaniotis; R S Zitomer

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PubMed · 10849660

Rox1 mediated repression. Oxygen dependent repression in yeast.

A J Kastaniotis·R S Zitomer

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Abstract

For a large number of oxygen-regulated genes in the facultative aerobe, Saccharomyces cerevisiae, the presence of oxygen is sensed through the ability to use oxygen for heme biosynthesis. Heme induces the transcription of oxygen-induced genes and represses the transcription of hypoxic genes. Repression is mediated by the Rox1 protein in conjunction with the Ssn6/Tup1 general repression complex. The differential repression of hypoxic genes results from a combination of the tightness of Rox1 binding to the regulatory region of specific hypoxic genes and the presence or absence of binding sites for Mot3 which enhances Rox1 repression.

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Aerobiosis Anaerobiosis Base Sequence Binding Sites DNA, Fungal DNA-Binding Proteins Fungal Proteins Gene Expression Regulation, Fungal Genes, Fungal Nuclear Proteins Oxygen Repressor Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Journal Article Review

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A J Kastaniotis, R S Zitomer. 2000. Rox1 mediated repression. Oxygen dependent repression in yeast.. https://pubmed.ncbi.nlm.nih.gov/10849660/

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