Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods.

R Jelliffe; A Schumitzky; M Van Guilder

doi:10.1097/00007691-200006000-00019

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Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods.

R Jelliffe·A Schumitzky·M Van Guilder

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Abstract

As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.

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Algorithms Amikacin Animals Anti-Bacterial Agents Bayes Theorem Computer Simulation Humans Models, Biological Models, Statistical Nonlinear Dynamics Pharmacokinetics Statistics, Nonparametric Vancomycin Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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R Jelliffe, A Schumitzky, M Van Guilder. 2000. Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods.. https://doi.org/10.1097/00007691-200006000-00019

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